ZFIN Image: Sneider et al., 2024, FIGURE 2

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Figure Caption

FIGURE 2

EV cargo is affected by matrix stiffness. A, Schematic of EV secretion by cancer cells on standard plastic, tumor (25 kPa) stiffness and normal tissue (0.5 kPa) stiffness. B, Silver stain of EV isolated proteins. C, Clustergram of EV protein abundance values. The color scale corresponds to the log₂ normalized z-scored abundance values scaled to −2 and 2 for visual clarity. Three biological repeats. See also Supplementary Table S2. D, Gene ontology pathway analysis using Metascape for MDA-MB-231 EV proteins enriched in stiff EVs over soft EVs (79). Three biological repeats.

Acknowledgments

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