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Figure 5.

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Publication: Cordero et al., 2024 - Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration
All Figures: Figures for Cordero et al., 2024

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Figure 5.

Transition from active to inactive chromatin state between 4 dpci and 14 dpci marks the start of the healing process. (A) Alluvial plot representing the dynamic chromatin states with reference point 14 dpci. (B) GO terms of the genes within the dynamic chromatin state groups presented in panel A. Example genes from each selected GO are presented to the right. The p-value was determined by enrichGO from clusterprofiler using ORA test; p-value *P < 0.05. (C) T-distributed stochastic neighbor embedding (t-SNE) visualization displaying the dynamic chromatin state transition groups (top) and the distribution of TF motifs (bottom). (D) Heatmap showing the enrichment of TF motifs in the clusters presented in (C, bottom panel). (E–H) Interaction network of TFs with enriched motifs in the largest cluster C1 associated with A_Ia transition (E), all clusters associated with A_Ia transition (F), with U_Ia transition (G) and cluster 3 associated with U_Pa transition (H) at 14 dpci.

Acknowledgments

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