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Fig. 7 Schematic diagram of ERK-activated CK-2 drives leg regeneration by regulating cell proliferation. When the leg of P. americana was amputated, the regenerative initiation signals will active ERK by up-regulating the phosphorylation levels. Activated ERK rapidly and continuously phosphorylates and activates CK-2 within blastema cell nuclear. Following activation, CK-2 can up-regulate DNA replication to promote cell proliferation and then the blastema formation to regeneration. However, down-regulation of ERK levels resulted in defected activation of CK-2 and failed leg regeneration.
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