Fig. 2

Fig. 2

Differentially expressed genes (DEGs) between the vitiligo lesional skin group and non-lesional skin group among GEO-datasets. a Volcano plot of DEGs among GSE75819 and GSE65127 datasets. The red and blue spots represented relative upregulated and downregulated DEGs based on |fold change| > 1 and adjusted p-value < 0.05. b Cluster heatmap of the top 100 DEGs sorted by log fold change. c Network of GO term enrichment analysis (red frame are pigmentation-related genes; purple frame are lipid biosynthetic process–related genes). d GO terms enrichment analysis of DEGs is presented (each band representing an enriched term or pathway, colored according to a −log10 p-value). e Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment by analysis of all differentially expressed genes (DEGs) (10 potentially vitiligo-relevant pathways and related genes). f Protein–protein interaction (PPI) network between PPAR signing pathway and pigmentation. G Gene-drug prediction of potential compounds.