ZFIN Image: Schneegans et al., 2024, Fig. 4

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Figure Caption

Fig. 4

Proteomics reveals enrichment of proteins connected to mitochondrial metabolism in cell lines differentially expressing HERC5. A Venn diagram depicting differentially regulated proteins analyzed by mass spectrometry (n = 3). Four proteins were found dysregulated in both HTB56 and A549 cell line, with three of them upregulated in cells with high HERC5 expression. B Volcano plots depicting differentially expressed proteins (FC > 1.5, p value < 0.05, n = 3). Significantly downregulated proteins in HTB56 OE and A549 PAR cells are shown in blue, while upregulated proteins are presented in orange. C GO term enrichment analysis showing the top five significantly enriched proteins (using R package [37], n = 3) D Visualization of proteins involved in these GO terms for biological processes by using R package GOplot [38]

Acknowledgments

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