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Fig. 2 Evaluation of cell viability and AChE activity in neuronal cells. (A) bEnd.3 and SK-N-SH cells viability after treatment with different concentrations of free DNZ, EVs-DNZ, and NPs-PLA-PEG-DNZ for 24h as determined by resazurin assay. Data presented are mean ± SEM (n = 6), **p < 0.01 vs control without treatment. (B) Effect of formulations on AChE inhibition in neuronal cells (SK-N-SH). Inhibition of the enzyme activity in percentage of the control group without treatment with n = 3 per group. ****p < 0.0001 vs control and ####p < 0.0001 vs PLA-PEG.
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