Fig. 3.

Fig. 3.

Affinities of p53TAD/MDM2 interactions. Affinities (K_D values) of extant and ancient p53TAD^15–27/MDM2 for different fishes mapped onto the phylogenetic tree. Key events that are discussed in the text are shown. Affinities for the reconstructed p53TAD^15–27/MDM2 are highlighted in yellow, the affinities of p53TAD^15–27/MDM2 for present-day fish species in gray and for the p53TAD^full-length/MDM2 in red. See Table 1 and supplementary table S1, Supplementary Material online for errors. The affinity at the node representing the divergence of fishes and tetrapods, marked with a star, was determined previously (Mihalič et al. 2023).