Fig. 3

Fig. 3

FGF19 promotes NPC growth and positively correlates with MVD in vivo. A: CNE2 cells transfected with shNC or shFGF19 were subcutaneously injected into nude mice. Representative pictures of NPC xenografts in nude mice are shown. B: The weights of the excised xenografts in the two groups. C: The volumes of the excised xenografts in the two groups. D: Representative results of immunohistochemical staining of FGF19, CD34 and Ki67 in xenograft sections. Red arrows indicate microvessels. E: Spearman correlation between FGF19 expression and MVD in tumour xenografts. The Pearson correlation coefficient (r²) and P value are shown. F: The column shows relative positive areas of FGF19 and Ki67 in xenografts according to the IHC results. G: Representative results of high and low immunohistochemical staining of FGF19 and CD34 in NPC tissues. Red arrows indicate microvessels. H: Spearman correlation between FGF19 expression and MVD in 10 NPC tissues. Pearson correlation coefficient (r²) and P value are shown. Data are presented as the mean ± SD of three independent assessments. *P < 0.05, **P < 0.01, ***P < 0.001