ZFIN Image: Nys et al., 2024, Figure 5

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Figure Caption

Figure 5

Apela and vascular plexus remodeling molecule network. (A) The STRING network view. Combined screenshots from the STRING website, which has been queried with a subset of proteins involved in the formation and remodeling of vascular vessels (Notch, VEGF, Ephrin, Hedgehog, TGF, COUP-TFII, FOXC2 and others. Colored lines between the proteins indicate the interaction evidence. (B, C) Relative expression of indicated VWF, IGFPB3, ESM1, VEGFR2, Apela, Apln and Aplnr mRNA in pooled fin zebrafish (15–20/per experiment) treated with Apela (B) or Mo-Apela (C). (D) STRING network queried with the same subset of proteins in (A) and the set of the angiogenic proteins: VWF, IGFPB3, ESM1, VEGFR2, Apela, Apln and Aplnr. Red lines between the proteins indicate the new interaction evidence. For (B) and (C), results are shown as means ± S.E. of three experiments performed in triplicate. *p < 0.05.

Acknowledgments

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