Figure 3.

Figure 3. Nematostella and Bilateria share BMP signaling targets, which predominantly encode transcription factors and signaling molecules.

(A) Overlap of BMP signaling targets at comparable embryonic stages in the three-way comparison of Nematostella, Drosophila (Deignan et al., 2016), and Xenopus (Stevens et al., 2017). Orthology links were deduced by NCBI BLASTP of the respective proteomes with a cut-off e-value ≤ 1e-5, and reciprocal best BLAST hits were determined using the bit score. (B) Transcription factors and signaling molecules represent more than 60% of pSMAD1/5 targets shared between Nematostella (Nve), fly (Dme), and frog (Xla). (C) Gene names of orthologous targets shared between Nematostella, fly, and frog. For targets shared with Nematostella, genes with known expression patterns in the embryo are underlined, while genes expressed asymmetrically along the directive axis are underlined and bold.