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Fig. 1 A unique N-terminal found in zebrafish cell division cycle 10 (Cdc10)-dependent transcript 1 (Cdt1), specific to bony fishes. (a) Functional-domain prediction of zebrafish Cdt1 protein. The grey box represents Cdt1 protein; numbers depict amino acids. The 53 unique amino acids in the N-terminal domain are boxed in orange. (b) Multiple alignment of Cdt1 protein sequences obtained from thirteen organisms including: zebrafish (Danio rerio), four species in the Cypriniformes order (Cyprinus carpio, Labeo rohita, Sinocyclocheilus anshuiensis, and Ctenopharyngodon idella), human (Homo sapiens), mouse (Mus musculus), rat (Rattus norvegicus), fruitfly (Drosophila melanogaster), worm (Caenorhabditis elegans), fission yeast (Schizosaccharomyces pombe), thale cress (Arabidopsis thaliana), and rice (Oryza sativa), at N-termini. Red text: similarity within a group; Blue box: similarity across groups; Dots: gaps.