ZFIN Image: Larsson et al., 2024, Fig. 7

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Figure Caption

Fig. 7 Study design and workflow.

Characterization of cell lines was performed using key marker for breast cancer (androgen receptor [AR]). Drug screening was performed using 18 drugs on 10 cell lines, and proteasome activity was measured for proteasome inhibitors to measure their ability to suppress the β5 site on the 20 S proteasome. The synergistic effect and inhibitory potency of 13 drug combinations were tested on five cell lines (CAL-148, HCC38, HCC1806, MCF-7 and MDA-MB-468). The data obtained in monotherapy were used to predict potent drug combinations by IDACombo. The predicted combinations plus combinations used in clinical practice were evaluated. This figure was designed using assets from Freepik.com (https://www.freepik.com/free-vector/set-female-breast-augmentation_2413429.htm#query=breast%20anatomy&position=5&from_view=search&track=sph).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Discov