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Fig. 2 All eleven proteasome inhibitors were tested for their ability to inhibit the activity at the β5 proteasome site.
Bortezomib and delanzomib show 95% and 55% inhibition at 1000 nM, and at 10000 nM they inhibit activity to 100% while MLN-9708 (51%), MLN-2238 (33%), and MG-132 (25%) inhibit the β5 site to a small extent. Statistically significant differences in the suppression of chymotrypsin-like activity in the proteasome between various doses of proteasome inhibitor were determined using the paired
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