ZFIN Image: Mi et al., 2023, Fig. 14

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Figure Caption

Fig. 14 The effect of N2 neutrophils on liver fibrosis in ATP7B-KO mice. (A) Representative images of Sirius red staining in paraffin-embedded liver sections from vehicle-, SM16-, 5-aza–, STATTIC-, or GW311616A-treated mice. Scale bar: 100 μm. qPCR of fibrogenic genes in (B) Tgfβ1, (C) Col1a1, (D) Col1a2, and (E) vimentin in wild-type and ATP7B-KO mice liver upon vehicle, STATTIC, or GW311616A treatment. n = 5∼6 mice/group. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001. (F) Upper panels: Representative images of Sirius red staining in paraffin-embedded liver sections from 16-week-old and 24-week-old wild-type and ATP7B-KO mice. Scale bar: 100 μm. Lower panel: Macroscopic liver pathology in 24-week-old wild-type and ATP7B-KO mice. WT, wild-type.

Acknowledgments

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