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Fig. 8 The development of liver defects in ATP7B-KO mice. (A) Body weight in 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. n = 5?6 mice/group. ?P < .05, ???P < .001. (B) Liver body ratio in 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. n = 5?6 mice/group. ???P < .001. Serum activities of (C) ALT, (D) AST, (E) Triglyceride, (F) TChol, (G) low-density lipoprotein cholesterol (LDL-C), and (H) HDL-C in 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. n = 5?6 mice/group. ?P < .05, ??P < .01, and ???P < .001. (I) Representative H&E images in liver sections from 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. Scale bar: 100 ?m. WT, wild-type.