|
Fig. 8 The development of liver defects in ATP7B-KO mice. (A) Body weight in 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. n = 5～6 mice/group. ∗P < .05, ∗∗∗P < .001. (B) Liver body ratio in 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. n = 5～6 mice/group. ∗∗∗P < .001. Serum activities of (C) ALT, (D) AST, (E) Triglyceride, (F) TChol, (G) low-density lipoprotein cholesterol (LDL-C), and (H) HDL-C in 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. n = 5～6 mice/group. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001. (I) Representative H&E images in liver sections from 6-, 8-, 16-, and 24-week-old wild-type and ATP7B-KO mice. Scale bar: 100 μm. WT, wild-type.