IMAGE

Fig. 8.

ID: ZDB-IMAGE-240129-139
Publication: Koosha et al., 2023 - Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification
All Figures: Figures for Koosha et al., 2023

Image

Figure Caption

Fig. 8.

Smad-mediated BMP signalling is decreased in the perichondrium region of heat-shocked, dnBMPR zebrafish embryos. (A-D′) Levels of p-Smad1/5/9 immunoreactivity appeared reduced in perichondral cells of heat-shocked dnBMPR ceratohyals at 72 hpf (i.e. 48 h after 20-min heat shock). (E) Quantitative image analyses (n=3 for each group) revealed significant decreases in p-Smad1/5/9 levels in both nuclei and non-nuclear regions of perichondral cells in heat-shocked dnBMPR zebrafish, compared with each control group (*P<0.05, one-way ANOVA and paired Student's t-test). Scale bars: 50 μm. a.u., arbitrary units; ColII, Collagen type II; HS, heat-shocked; pc, perichondral cells; wt, wild type.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development