IMAGE

FIGURE 6

ID

ZDB-IMAGE-240118-18

Genes

Antibodies

Publication

Chen et al., 2024 - Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development

All Figures

Figures for Chen et al., 2024

Image

Figure Caption

FIGURE 6

Deficient dopaminergic and histaminergic neurons are found in angpt1^–/– and itgb1b^–/– brains but normally developed in tek^–/– brains. TH1-immunostaining images of 4-dpf shown in (A)angpt1^+/+(B)angpt1^–/–(C) Quantification of TH1-positive cell numbers in the Hc region (N = 8 per group, P < 0.0001) (D)itgb1b^+/+(E)itgb1b^–/–(F) Quantification of TH1-positive cell numbers in the Hc region (N = 7 per group, P = 0.0153) (G)tek^+/+(H)tek^–/– and (I) Quantification of TH1-positive cell numbers in the Hc region (N = 8 per group, P = 0.5392). Histamine (His)-immunostaining images of 4-dpf show in (J)angpt1^+/+(K)angpt1^–/–(L) Quantification of His-positive cell numbers in the Hc region (N = 8–9 per group, P = 0.003) (M)itgb1b^+/+(N)itgb1b^–/–(O) Quantification of His-positive cell numbers in the Hc region (N = 7 per group, P < 0.0001) (P)tek^+/+(Q)tek^–/– and (R) Quantification of His-positive cell numbers in the Hc region (N = 8 per group, P = 0.8814). (A’–Q’) Show the high magnification images corresponding to the white rectangular area in the Hc region shown in (A) and an equivalent area in (B–Q). TH-positive cells display in magenta, and His-positive cells display in green. Hc, caudal hypothalamus. Data represent the mean ± SD. n unpaired student t-test was used for statistical analysis, *p < 0.05, **p < 0.01 and ****p < 0.0001. Scale bars are 200 μm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.