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Fig. 4 Effects of disrupting fgf3 or fgf8a. (A-I) Dorsolateral views showing expression of pax5 and pou3f3b at 24 hpf in fgf3−/− and fgf8a−/− mutants, as indicated at the top. White arrows (B, C) mark boundaries of pou3f3b normally seen in wild-type embryos, black arrows mark altered boundaries observed in fgf3−/− mutants, and dashed lines mark positions of the anterior and posterior boundaries of the lumen. Distances in μm separating the edges of the pou3f3b domain from that anterior and posterior poles are indicated. Asterisks indicate significant differences from the control. (D-I) fgf8a−/− mutants with one or two otoliths per ear, as indicated on the side, were analyzed separately.