ZFIN Image: Lawir et al., 2024, Fig. 7

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Figure Caption

Fig. 7 Transcriptional landscapes in dnmt1 and pole1 mutants.

a Dynamic changes in transcriptomes of dnmt1 and pole1 single and double mutants, as indicated by principal component analysis. b Venn diagram indicating the overlap of differentially expressed genes for down-regulated and up-regulated genes in fish of the indicated genotypes. c Four clusters of co-regulated genes are identified in dnmt1 mutant fish; each column represents a biological replicate. d Co-regulation of groups of genes in (c) identifies 2 gene clusters with restored wild-type levels in dnmt1/pole1 double mutants; box plots (mean; box, upper/lower quartile; whiskers, minimal/maximal values).

Acknowledgments

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