ZFIN Image: Gounou et al., 2023, Fig. 6

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Fig. 6

Genetic inhibition of ANXA2 prevents invasion and metastasis processes of MDA-MB-231 cells in zebrafish. A Control (n = 21) or shANXA2 MDA-MB-231 (n = 24) cells were injected in the perivitelline space of Casper zebrafish embryos. Tumor imaging was done by fluorescence microscopy at 3-, 28- and 52 hpi through the tdTomato fluorescent protein constitutively expressed in MDA-MB-231 cells. Inset displays magnified image of a portion of the tail with metastases (white arrows). B The relative tumor size within the perivitelline space has been measured in embryos either injected by control or shANXA2 cells. C The percentage of embryos, which presented caudal or head metastases was quantified at 28 hpi. D Mortality rate was calculated at 52 hpi

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