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Figure Caption
Fig. 1 Schematic of the human STAT5b protein adapted from Ramirez et al., 2020. The three variants studied are indicated: p.Gln474Arg located in the DNA binding domain, and p.Ala630Pro and p.Lys632Asn located in the SH2 domain. NH2, amino acids 1–144; Coiled-coil, amino acids 144–330; DNA binding, amino acids 330–496; linker, amino acids 496–592; SH2, amino acids 592–685; TAD, amino acids 707–787. Tyrosine 699 (Y699) can be phosphorylated by JAK2 and other kinases.
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Full text @ Hum. Mol. Genet.