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Fig. 4 Network pharmacological analysis for EN related to osteoporosis. Venn diagram of (a) EN targets and (b) OP-related genes. (c) Volcano plot of DEGs obtained from GSE35958. (d) Venn diagram of target genes of EN in OP. (e) PPI network of EN targets in OP. (f) Venn diagram of hub genes of EN in OP. (g) Target?signaling pathway/biological process interaction network of EN in OP. Note: left single node, EN; right single node, OP; middle nodes in grid arrangement, overlapping EN-OP targets; upward side nodes in circular arrangement, biological process; downward side nodes in circular arrangement, signaling pathways. (h) Biological process (BP). (i) Molecular function (MF). (j) Cellular component (CC). (k) KEGG pathway. DEGs, differentially expressed genes; EN, eurycomanone; OP, osteoporosis; PPI, protein?protein interaction; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.