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Fig. 6 Pknox2 controls multiple key genes in the inner ear. (A) Heatmap of top upregulated and downregulated genes by P value and log2FC, grouped based on their pattern of gene expression according to the Pknox2+/+ and Pknox2−/− samples. Each row represents a gene and each column represents a sample. (B) Scheme depicting −log10(padj) values of GO terms in g:Profiler for differentially expressed genes in Pknox2+/+ and Pknox2−/−. Top terms are numbered and displayed in the table below. (C) Functional association of 57 proteins comprising the Biological Process “transmission of nerve impulse” in STRING (V11). Circle colors indicate whether the protein is upregulated (red) or downregulated (blue) in Pknox2−/− mice.