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Fig. 7 Model for wound-induced hydraulic fissuring Overview of fissure formation during wound healing in zebrafish larval epidermis. (1) An unwounded tailfin showing an intact basal layer. (2) After wounding, osmotic gradients drive external fluid through the open wound. (3) The myosin II purse string contracts along the wound margin, further forcing the external fluid anteriorly into the epithelial tissue. (4) The combination of the hydrostatic and cytoskeletal forces causes the hydraulic fracturing of the basal cells and fissure propagation anteriorly to the wound. (5) The excess fluid is subsequently cleared by the surrounding basal cells via macropinocytosis over longer timescales.