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Figure 3

ID: ZDB-IMAGE-231016-73
Publication: Hodges et al., 2023 - Disrupting the Repeat Domain of Premelanosome Protein (PMEL) Produces Dysamyloidosis and Dystrophic Ocular Pigment Reflective of Pigmentary Glaucoma
All Figures: Figures for Hodges et al., 2023

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Figure 3

pmela mutants display systemic hypopigmentation and retarded eye size development. (A) Both pmela mutant alleles present with systemic hypopigmentation in homozygotes at 3 days post-fertilization (dpf). (B) Adult homozygous ua5030 zebrafish (−/−, top) display hypopigmentation when compared to heterozygous and wildtype fish. (C,D) Microphthalmia is observed in homozygous mutants from both alleles beginning by 4 dpf (days post-fertilization). Heterozygous pmela^+/ua5022 larvae show normal eye size, whereas heterozygous pmela^+/ua5030 larvae have reduced eye size. Considering the normal abundance of Pmela in pmela^+/ua5030 larvae (Figure 2E), this appears to be a dominant phenotype rather than haploinsufficiency.

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Acknowledgments

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