ZFIN Image: Hodges et al., 2023, Figure 3

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Figure 3

pmela mutants display systemic hypopigmentation and retarded eye size development. (A) Both pmela mutant alleles present with systemic hypopigmentation in homozygotes at 3 days post-fertilization (dpf). (B) Adult homozygous ua5030 zebrafish (−/−, top) display hypopigmentation when compared to heterozygous and wildtype fish. (C,D) Microphthalmia is observed in homozygous mutants from both alleles beginning by 4 dpf (days post-fertilization). Heterozygous pmela^+/ua5022 larvae show normal eye size, whereas heterozygous pmela^+/ua5030 larvae have reduced eye size. Considering the normal abundance of Pmela in pmela^+/ua5030 larvae (Figure 2E), this appears to be a dominant phenotype rather than haploinsufficiency.

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.