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Figure 6

ID: ZDB-IMAGE-231011-8
Publication: Ernst et al., 2023 - Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform
All Figures: Figures for Ernst et al., 2023

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Figure 6

qPCR results for inflammation associated gene expression in zebrafish larvae (a) Scheme of larvae treatment with SARS-CoV-2 spike protein and selected drugs. (b) qPCR results for zebrafish larvae treated with SPIKE protein. (c) qPCR results represented as a heatmap representing fold change with respect to treatment with DMSO without spike (− SPIKE + DMSO). The upregulation is shown in dark green and the downregulation in dark magenta. Significance calculated between DMSO with SPIKE-protein treated group (+ SPIKE + DMSO) and the rest. Each color box represents a mean of 6 biological replicates of 5 embryo pools (n = 6, Mann–Whitney U-test treatment vs. + spike + DMSO; *p < 0.05, **p < 0.01, ***p < 0.001).

Acknowledgments

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