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Publication: Karolczak et al., 2023 - Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy
All Figures: Figures for Karolczak et al., 2023

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Figure 4 Canalicular ultrastructure is disrupted in mtm zebrafish.

Electron microscopy of whole 7 dpf zebrafish was used to define liver ultrastructure. (A) Magnification (original magnification, ×5,000; scale bars: 5 μm) showing multiple hepatocytes, with bile canaliculi outlined by red dashed lines. Fragmentation of mtm canaliculi was already visible at this magnification. (B) Higher-magnification visualization of bile canaliculi (original magnification, ×14,000; scale bars: 2 μm). In the WT panel, canalicular microvilli are apparent (black dashed circle). In the mtm sample, the canaliculus is devoid of microvilli. Green arrows point to fragmented parts of the canaliculus. n = 3 zebrafish per genotype.

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