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Figure 6

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Publication: Fernandes et al., 2023 - Complement System Inhibitory Drugs in a Zebrafish (Danio rerio) Model: Computational Modeling
All Figures: Figures for Fernandes et al., 2023

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Figure 6

Comparative analysis of C5aR1 from D. rerio and H. sapiens. (a,b) C5aR1 proteoforms from D. rerio and H. sapiens showing similar peptide sequences identified in blue; (c) structural and physicochemical characteristics of C5aR1, showing charge and hydrophobicity; (c.1) arrows point to the C5aR1 cavitation and show the PMX205 receptor binding pockets and (d) the volume of the pockets; (e) structural and physicochemical characteristics of C5aR1 in three-dimensional form, showing the properties of amino acid residues in terms of hydrophobicity and positive and negative charges; the graphs (f) show the distribution of these amino acids according to the area in Å; (g) distribution of hydrogen bond networks. The numerical sequences refer to the colors that represent each network of hydrogen bonds.

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