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Fig. 3
Differences in gene and protein expression in FSCN1 KO compared with ctrl H295R cells. (A) Heatmap of differentially expressed genes (DEG) in FSCN1 KO cells compared with control cells. The yellow bar indicates genes upregulated, the blue bar genes downregulated in FSCN1 KO cells, respectively. Log2 scale is shown. (B) Gene Ontology (Biological Processes) categories enriched in DEG. (C) Intersection of the lists of transcripts and proteins found differentially regulated in FSCN1 KO vs control cells. SCIN and VSNL1 were upregulated at both the transcript and protein levels in FSCN1 KO cells. (D) Transcript levels of SCIN and VSNL1 measured by RT-qPCR in FSCN1 KO and control H295R cells. n (independent experiments) = 4. Mean ± SD is shown. *P < .05, t test.
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Full text @ Int. J. Cancer