ZFIN Image: Nakamae et al., 2023, Figure 4.

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Figure Caption

Figure 4.

The result of risk assessment in DANGER analysis using RNA-seq data derived from WT and GRIN2B edited iPSC-derived cortical neurons. (A) An example of the annotation table for DANGER analysis. The table includes GO ID, GO term, number of MMs (n), and the counts of n-MM off-target genes belonging to a specific GO term. (B) The formula for phenotypic off-target risk (D-index). An example of the calculation is shown on a lower box. (C) Distribution of the D-index of each GO term. The sum of all D-indexes and the number of D-indices (N) were labeled on the top right.

Acknowledgments

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