ZFIN Image: Hu et al., 2023, Fig 7

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Figure Caption

Fig 7 Tp promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux.

In this study, we demonstrated that Tp activated mTORC1 signalling to inhibit the nuclear translocation of transcription factor EB (TFEB), decreasing lysosomal biogenesis and causing autophagy arrest and autophagosome accumulation. Autophagosome accumulation was demonstrated to be a key mechanism by which Tp promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux.

Acknowledgments

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