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Fig. 8
Effects of four different 5-HT7R selective agonists combined with antagonist (SB269970) on melanin synthesis in B16F10 cells. (A) Left, observation of four different 5-HT7R selective agonists on melanin granules in B16F10. Right, the relative melanin content was calculated by Image J (n = 3). *p < .05, compared with the Ctrl. (B) Observation of four different 5-HT7R selective agonists on dendritic morphology in B16F10 cells. *p < .05, compared with the Ctrl. (C) Effect of four different 5-HT7R selective agonists combining with SB269970 on melanin content in B16F10. *p < .05, compared with the Ctrl, #p < .05, compared with the SB269970. (D) Left, wound healing experiment of four different 5-HT7R selective agonists on cell migration at 0, 24, 48, and 60 h in B16F10 cells. Right, the relative wound closure area was calculated by Image J (n = 3). *p < .05, compared with the Ctrl. Each value represents the mean ± SEM (n = 5). (E) Effect of four different 5-HT7R selective agonists on activation of PKA C-? protein in vitro. Representative image from three independent experiments is shown.
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