The downregulation of Kdm6b represses cell proliferation and disrupts rosette assembly during primordium migration. a, b The diagram of rosette organization in controls and kdm6bb-MO embryos. c–h Representative images show the comparison in number of BrdU labeled proliferating cells between controls embryos (c, e, g) and Kdm6b-deficient mutants (d, f, h) at 36 hpf. Red arrows indicate the rosette-shaped clusters of the primordium (c). Scale bars mark the 10 μm scale. i Significant difference in quantification of BrdU index in control embryos and kdm6bb-MO embryos. Data are recorded as mean (minimum and maximum values). *p < 0.05
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