ZFIN Image: Schäfer et al., 2023, Fig. 10

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Fig. 10

Current model of ES24 mechanism of action in Gram-positive and Gram-negative bacteria in comparison with NFT. NFT affects different cellular processes, including DNA packing; localization of DNA-binding proteins; and membrane integrity, membrane fluidity, and membrane protein binding. No clear differences were observed in its mechanism against E. coli and B. subtilis. ES24 affects Sec-mediated protein secretion and causes DNA damage in both organisms, but only affects cell division in E. coli. Reporter protein functions: MinD and DivIVA, cell division site regulation; FtsZ, cell division; SecA, Sec-dependent protein secretion; AtpA, ATP synthesis; RecA, DNA damage repair; DnaN, replication; RpoC, transcription; RpsB: translation.

Acknowledgments

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