ZFIN Image: Petrillo et al., 2023, Fig. 8

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Fig. 8

Endothelial FLVCR1a is required for proper angiogenesis. A Schematic representation of endothelial FLVCR1a expression during angiogenic vascular growth. FLVCR1a is low in the quiescent vasculature and strongly increases in aECs that have to proliferate and arrange in a new vascular network. Once the de novo vasculature is fully formed and mature, FLVCR1a levels decrease. B Schematic representation of vascular defects upon endothelial Flvcr1a targeting. Given the importance of FLVCR1a in aECs, FLVCR1a deficiency does not affect fully formed vascular networks. Conversely, endothelial-specific FLVCR1a targeting severely compromises neo-angiogenesis by reducing vascular expansion, ECs proliferation, and pericyte recruitment while increasing vessel permeability

Acknowledgments

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