ZFIN Image: Henderson et al., 2023, Figure 3

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Figure 3

PR3-induced MGC stimulates proinflammatory cytokines. Cytokines and chemokines were measured in MGC cell culture supernatants in unstimulated, PR3-stimulated or MPO-stimulated cells (A). IL-6 production increased in the presence of PR3 in patients with GPA compared with patients with MPA, but was not significantly different from HC (B). A reduction in IL-6 production was seen in patients with GPA following stimulation with MPO. Monocyte Chemoattractant protein (MCP)-1 production (C) was also increased in patients with GPA following stimulation with PR3 compared with patients with MPA. MPO stimulation did not have any effect on differences in IL-6 or MCP-1 production. Values plotted as median and IQR; *p<0.05, **p<0.01, ***p<0.001. Difference between multiple conditions determined by two-way ANOVA. ANOVA, analysis of variance; GPA, granulomatosis with polyangiitis; HC, healthy controls; IL, interleukin; IFN, Interferon; MGC, multinucleated giant cells; MPA, microscopic polyangiitis; MPO, myeloperoxidase; PR3, proteinase 3; TNF, tumour necrosis factor.

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