ZFIN Image: Henderson et al., 2023, Figure 5

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Figure 5

PR3, MAC-1 and PAR-2 expression is increased on the monocytes from patients with GPA. Following staining, the proportions of classic (CD14hi CD16lo), intermediate (CD14hi CD16hi) and non-classic (CD14lo CD16hi) monocytes were calculated. There was a significant increase in intermediate monocytes in patients with GPA compared with healthy controls and non-classic monocytes in patients with GPA compared with patients with MPA (A). PR3, MAC-1 and PAR-2 expression on the monocytes of patients with CD14-positive GPA was significantly increased compared with healthy controls and patients with MPA (B). Values plotted as median and 95% CI; *p<0.05, **p<0.01, ***p<0.001. Difference between conditions determined by one-way and two-way ANOVA tests. ANOVA, analysis of variance; GPA, granulomatosis with polyangiitis; MAC-1, macrophage -1 antigen; MPA, microscopic polyangiitis; PAR-2, protease-activated receptor-2; PR3, proteinase 3.

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