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Fig 3 Developmental toxicity induced by 2 μg/ml propofol.
(A) Injury and deformity rate from 24 hpf to 96 hpf in zebrafish. Three independent experiments of 50 embryos for each group were carried out; repeated measures ANOVA with Bonferroni correction. (B) Changes of specific types of deformities and injuries with the growth and development of zebrafish. Three independent experiments of 50 embryos for each group were carried out. (C) Image of 3 dpf zebrafish under a stereoscope microscope; scale bar = 1 mm; magnification = ×10. (D) Body length of zebrafish from 24 hpf to 96 hpf; n = 7 for each group; two-way ANOVA with Bonferroni correction. (A, D) No same letter indicates a significant difference between different time points for the same group (P < 0.05); # indicates a significant difference between the control group and the 2 μg/ml propofol group at this time point (P < 0.05).