ZFIN Image: Aljiboury et al., 2023, Fig 7

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Figure Caption

Fig 7 Model depicting KV lumen and cilia formation across KV developmental stages.

Centrosome depicted in magenta, cilia in cyan and CFTR in green. (A-B) At the pre-rosette stage (A) a proportion of centrosomes start to assemble cilia that then reposition towards the center of the KV at the rosette stage (B) in a Rab11 and Rab35 dependent manner. In (B), Rab11 and Rab35 mediate CFTR transport to the apical membrane. (C) The rosette stage then transitions to a lumen stage where most of the centrosomes locate at the CFTR-positive apical membrane and extend their cilia into the lumen where cilia elongate to their full length in a Rab8 dependent manner.

Acknowledgments

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