ZFIN Image: Arroyo et al., 2023, Figure 5

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Figure Caption

Figure 5

Reduction in pathology-associated biomarkers in human organotypic 3D skin model of AD. (A) Experimental design. Transcript levels of the indicated genes encoding markers of inflammation (B–D,H), epidermal differentiation (E,F) and proliferation (G) were determined in human organotypic 3D skin pretreated with 10 ng/mL IL13 and IL4 in the presence of vehicle (DMSO) or the indicated inhibitors. Protein levels of interest were also determined by Western blot (I,J). The mean ± SEM of each group is shown. Results are representative of 3 independent experiments. p values were calculated by Kruskal–Wallis test and Dunn’s multiple comparisons test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001. M, molecular weight markers.

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