ZFIN Image: Guan et al., 2023, Figure 5

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Figure Caption

Figure 5

Treatment of rhGH alleviated the hyperactivity-like phenotype of ghrelin^?/? zebrafish. (A) Representative images of zebrafish swimming tracks. (B) Quantification of the spontaneous locomotor distance of zebrafish over 20 min (Mean � SEM. **P<0.05, ****P<0.0001, NS=no significance, F _{1,26 (interaction)} =6.884, two-way ANOVA). (C) The activity recorded was the mean average swimming distance of adult ghrelin^?/? and adult ghrelin^+/+ zebrafish during 20 min under light-changing condition (first 5 min dark, next 5 min light stimulation, then 5 min dark, and finally 5 min light). (D) The swimming distance of the zebrafish is in the dark (Mean � SEM. *P<0.05, ****P<0.0001, NS=no significance, F _{1,27 (interaction)} =10.84, two-way ANOVA). (E) The swimming distance of zebrafish under light stimulation (Mean � SEM. *P<0.05, ****P<0.0001, NS=no significance, F _{1,26 (interaction)} =5.173, two-way ANOVA). (F) The swimming distance of zebrafish in the light (Mean � SEM.*P<0.05, ****P<0.0001, NS=no significance, F _{1,27 (interaction)} =0.5135, two-way ANOVA). (Ghrelin^+/+ zebrafish injection vehicle, n=8; ghrelin^+/+ zebrafish injection rhGH, n=9; and ghrelin^?/? zebrafish injection vehicle, n=7, ghrelin^?/? zebrafish injection rhGH, n=8).

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)