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Figure 2. A conserved non-coding element, jaw joint regulatory sequence 1 (JRS1), identified using mVISTA and MEME.
(A) mVISTA alignment of vertebrate Nkx3.2 loci, using the spotted gar locus as reference. Peaks indicate conserved sequences >50% identity, coloured peaks indicate >70% identity. Dark blue peaks indicate conserved exon sequences, pink indicates conserved non-coding sequences. (B) Shared sequence motifs (1–4) in the core ~245 bp sequence of JRS1 in different species identified with MEME analysis. p values indicated per species (horizontal) and per motif (vertical). (C) Relevant transcription factor-binding sites predicted by Tomtom at motifs 1–4 with associated p values for each match.