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Figure 6
TCA and GCA increase the expression of FXR. (A) Increased FXR mRNA levels in bile acids-supplemented macrophage inflammation model. (B) Increased FXR downstream genes mRNA levels in bile acids-supplemented macrophage inflammation model. (C,D) Representative fluorescent images (C) and fluorescence quantification (D) of FXR immunofluorescence. (E) Schematic diagram of the proposed anti-inflammation mechanism of TCA and GCA. All the data are presented as the mean ± SEM of three independent experiments. # Compared with the control group; * compared with the model group; *, p < 0.05, ## or **, p < 0.01.
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