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Fig. 8
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- Mattis et al., 2023 - Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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Fig. 8
Genetic variation at the RREB1 locus influences human beta cell function. Insulin content (a, c, e) and glucose-stimulated insulin secretion (b, d, f) in human donor islets from carriers of RREB1 variants: (a, b) rs9379084 (GG, n=180; GA, n=38), (c, d) rs9505097 (CC, n=168; CT, n=219) and (e, f) rs112498319 (CC, n=50; CA, n=109; CC, n=50). Data are presented as means±SEM. **p<0.01, ***p<0.001 (one-way ANOVA)
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