ZFIN Image: Sahin et al., 2022, Fig. 5

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Figure Caption

Fig. 5 Figure 5. CNSL derivatives activate PPAR? target genes in primary hepatocytes in a gene-selective manner. Primary hepatocytes were isolated from wild-type (WT) mice and incubated with vehicle (Veh, DMSO), 50 ?M CNSL derivatives or 10 ?M of positive controls: WY14643 (WY, PPAR? agonist), GW7647 (GW, PPAR? agonist), muraglitazar (Mura, PPAR?/? agonist), rosiglitazone (Rosi, PPAR? agonist) for 16 h. Expression of fatty acid uptake genes Fabp1 (A) and Cd36 (B), and fatty acid oxidation genes, Fgf21 (C) and Pdk4 (D) were analyzed by quantitative polymerase chain reaction (QPCR). Veh mRNA expression was set to 1. Data represent mean � SD (N = 3). *P < 0.05 vs Veh using one-way ANOVA with Holm??id�k correction.

Acknowledgments

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