ZFIN Image: Kowald et al., 2023, Figure 4

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Figure 4

Tumor dissemination is not significantly impacted by BCG treatment of zebrafish UM-UC-3 tumor xenografts. (A) Cartoon showing the outline of the experiment. Fluorescently labelled UM-UC-3 tumor cells alone or mixed with viable or heat-inactivated BCG were injected into the PVS of 48 h old zebrafish larvae. Alternatively, viable BCG was injected intravenously in subcutaneous tumor-bearing larvae. (B) Fluorescent micrographs of the caudal hematopoietic plexus of control and BCG- (co-)injected tumor-bearing larva at 3 days post-implantation. Red dots represent disseminated tumor cells. (C) Graph showing the quantified number of cells present in the caudal hematopoietic plexus in the different treatment groups. n = 24 injected embryos per group; ns = not significant.

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