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Fig. 5

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Publication: Guo et al., 2023 - Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis
All Figures: Figures for Guo et al., 2023

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Fig. 5

A molecular network required for osteoclast differentiation is modulated by cdkn1a.

a Differentially expressed genes (|log2Fold change | > 0.3 and FDR < 0.05 were used as thresholds) after cdkn1a knockout (n = 2437 DEGs). b Heatmap of the osteoblast- and osteoclast-associated genes between the cdkn1a^Case9/sgRNA and control groups. c The expression changes of representative DEGs after cdkn1a knockout were validated by qRT‒PCR. d Functional enrichment analysis showing significant KEGG pathways among cdkn1a-regulated genes. e Global view of the cdkn1a-mediated molecular network required for osteoporosis. f GSEA showed that osteoclast differentiation was negatively enriched using cdkn1a-regulated genes.

Acknowledgments

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