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Figure 4
Gata3 dataset yields chemical modifiers via LINCS. The top 100 up- and down-regulated genes affected by gata3 knockdown and rescue were queried against the LINCS L1000 dataset. The chemical modifiers whose profile most resembled the transcriptomic signature were selected for testing. Modifiers that significantly reduced the intact trabeculae count in mild mutant phenotype are listed under “enhances phenotype”, while those that significantly increased the trabeculae count in the severe mutant phenotype are listed under “suppresses phenotype”. Created with BioRender.com.
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Full text @ Int. J. Mol. Sci.