ZFIN Image: Shi et al., 2023, Figure 4

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Figure Caption

Figure 4

Pseudotime analysis reveals developmental trajectories in the zebrafish inner ear.

(A,B) Pseudotime analysis of macular cells showing simulated developmental trajectories of a putative bipotent progenitor population into hair cell and supporting cell clusters. (C,D) Changes in putative progenitor markers along (C) hair cell and (D) supporting cell trajectories. fat1a and pard3bb only decrease along the hair cell trajectory, while fgfr2 and igsf3 decrease along both hair cell and supporting cell trajectories. (E) Transient expression of early hair cell genes dla and atoh1a along hair cell trajectories. (F) Increases in gene expression levels of gfi1aa and myo6b along hair cell trajectories. (G) Increases in stm and lfng along supporting cell trajectories.

Acknowledgments

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