Figure 6

Figure 6

Comparison of our zebrafish radiation group vs space flown mouse and the zebrafish induced torpor group vs hibernating bear. The results between the zebrafish radiation model and the space flown mouse show shared upregulation of genes involved in sulphur dioxygenase activity, telomerase RNA reverse transcriptase, alpha-sialidase activity, and fibroblast growth factor receptor activity. Shared downregulated genes included the estrogen receptor (ESR1), and genes involved in cytoskeleton formation and cellular migration. Additionally, shared biological processes included lipid metabolism and response to endogenous stimuli. Comparison of the torpor group versus the hibernating bear showed shared upregulation of anti-apoptotic genes, DNA repair genes, pro-survival genes, antioxidant genes, and Wnt signaling. Shared downregulated genes included anticoagulant genes, while dysregulated genes were involved in lipid oxidation and cholesterol synthesis. Furthermore, shared BP included a response to ROS, cell cycle checkpoints, telomere lengthening, and nitric oxide synthase. Created with BioRender.com.